At higher doses: pleasant sedation, a sensation of floating between dreams and reality (nodding), provides the characteristic warmth associated with opioids, realistic dreams. Possible feelings of bliss, positive thoughts. During meditation after using kratom, there may be a noticeable influx of positive thoughts and energy for life, euphoria, happiness, and delight. Improves sexual performance. Possibility of prolonging erection.

The plant has strong analgesic properties, and it is possible that it helps in overcoming addiction to heroin, cocaine, and methamphetamine. Ongoing research even suggests that it may replace methadone in the treatment of opioid addiction. The main and most important alkaloids found in kratom are 7-hydroxymitragynine, which interacts with opioid receptors in the brain, and its stimulating effects are attributed to mitragynine, the second most important component. In addition to the two mentioned above, this depressant also contains 25 other alkaloids.